Faculty Profile

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Garimella Venkata sireesha

Associate Professor, Life sciences, GSS, VSP

sgarimel@gitam.edu | | |

Dr. Sireesha V Garimella holds a Master’s degree (M.Sc.) in Life Sciences from University of Hyderabad with a gold medal, and a Ph.D. degree in Molecular Reproduction and Development from the Indian Institute of Science (IISc), Bangalore. Subsequently, she pursued post-doctoral research at the Centre for Cellular and Molecular Biology (CCMB), Hyderabad, and at the National Cancer Institute (NCI) under the aegis of the National Institutes of Health (NIH), USA in the field of Molecular Oncology.

Research Publications

Sireesha V Garimella*, Siri Chandana Gampa and Pankaj Chaturvedi (2023) Mitochondria in Cancer Stem Cells: From an Innocent Bystander to a Central player in Therapy Resistance. Stem Cells and Cloning: Advances and Applications, 19-41
Siri Chandana Gampa, Sireesha V Garimella*, Santhi Latha Pandrangi (2023) NanoTRAIL-a promising path to cancer therapy. Cancer Drug Resistance, 6, 79-103
Pavan Kumar Rambatla et al., (2023) Prostate cancer stem cells: Their role in prostate cancer and new therapies to target them. Onkologia I Radiotherapia 17(3), 1-16
Garimella SV et al., (2014) Identification of novel molecular regulators of tumor necrosis factor-related apoptosis inducing ligand (TRAIL)-induced apoptosis in breast cancer cells by RNAi screening. Breast Cancer Research. Apr 17;16(2):R41
Garimella SV, Rocca A and Lipkowitz S (2012) WEE1 inhibition sensitizes basal breast cancer cells to TRAIL-induced apoptosis. Molecular Cancer Research January, 10(1): 75-85. (Selected as HIGHLIGHTS of the issue, 10(1): 1)

Ongoing Research Projects

Studies on the role of BAG-1 as a TNF-Related Apoptosis Inducing Ligand (TRAIL)-sensitizer in breast cancer cells (UGC) 2019-2022
Characterization of the sensitizers of TNF-Related Apoptosis Inducing Ligand (TRAIL)-induced apoptotic pathway identified by an RNAi screen approach, and to elucidate their role as chemotherapeutic agents in breast cancer cells. (DST-SERB) 2019-2022
Induction of ferroptosis in drug tolerant Oral cancer stem cells (CSCs) - Effect on CSC self-renewal and molecular mechanisms involved therein. (Co-PI) 2019-2022
Screening of TRAIL-Responsive Breast Cancer Patients in South India (GITAM-SEED) 2019-21

Expertise

Cell and Molecular Biology of Cancers
RNAi silencing and High throughput Screens
Mammalian Development
Stem Cell Biology

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Garimella Venkata sireesha

Associate Professor, Life sciences, GSS, VSP

Research Publications

Ongoing Research Projects

Expertise

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