slone@gitam.edu
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I am a behavioral neurogeneticist specializing in the study of time, memory, sleep, and love. Utilizing fruit flies as a model organism, we investigate the neuronal mechanisms underlying these behaviors by selectively blocking specific groups of neurons to understand their roles. I obtained my Ph.D. from JNCASR Bangalore. Subsequently, I pursued postdoctoral research at Johns Hopkins University in the USA and the University of Fribourg in Switzerland.
Research Publications
- Mechanosensory stimulation via Nanchung-expressing neurons can induce daytime sleep in Drosophila. Lone SR*, Potdar S, Venkataraman A, Sharma N, Rutvij K Kulkarni RK, Rao S, Vasu S* and Sharma VK. Journal of Neuroscience. 2021; 41:9403-9418. 4. This article was covered in news. https://neurosciencenews.com/motion-sleepiness-19467/ https://www.eurekalert.org/news-releases/931534 https://medicalxpress.com/news/2021-10-motion-sleepy-insight-fruit-flies.html
- Dopamine, sleep, and neuronal excitability modulate Ab42 -mediated forgetting in Drosophila Kaldun JC#; Lone SR#; Humbert A; Widmer YF; Stein JV; Tomchik S; Sprecher SG. PLoS Biology 2021;19(10),e3001412 # Authors contributed equally. This article was covered in public news. https://www.blick.ch/life/wissen/test-mit-fruchtfliegen-mit-schlaf-undepilepsie- medikament-gegen- alzheimer-vergesslichkeit-id16927569.html https://www.suedostschweiz.ch/wirtschaft/mit-schlaf-und-epilepsiemedikament- gegen-alzheimer-vergesslichkeit
- Sleep Interacts with Ab to Modulate Intrinsic Neuronal Excitability. Tabuchi M, Lone SR, Liu S,Liu Q, Zhang J, Spira AP, Wu MN. Current Biology 2015; 25:1-11. Commentary on paper by Alex C. Keene and William J. Joiner Neurodegeneration: Paying It Off with Sleep
- Or47b-neurons promote male-mating success in Drosophila. Lone SR, Venkataraman A, Srivastava M, Potdar S, Sharma VK. Biology letters 2015; 11(5).
- Peculiar sleep features in sympatric species may contribute to the temporal segregation. Mishra S, Sharma N, Singh SK and Lone SR*. (Journal of Comparative Physiology B) 2022:1- 14.
Ongoing Research Projects
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Seed grant from GITAM University
Expertise
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Sleep, Circadian rhythms, Memory, courtship, Alzheimer's disease,
