ssahoo4@gitam.edu
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Santosh Kumar Sahoo is from Bhubaneswar, Odisha. He holds a Ph.D. in Medicinal Chemistry from NIPER, Hyderabad. He has pharmaceutical industry experience as a Quality Control (Q.C.) officer, besides his research expertise in organic synthesis and Medicinal Chemistry. His research areas include the structure-based design of novel antibacterial and anticancer agents targeting drug resistance.
Research Publications
- Synthesis and structure-activity relationship of new chalcone linked 5-phenyl-3-isoxazolecarboxylic acid methyl esters potentially active against drug resistant Mycobacterium tuberculosis. European Journal of Medicinal Chemistry 2021, 222, 113580. https://doi.org/10.1016/j.ejmech.2021.113580.
- Bioevaluation of quinoline-4-carbonyl derivatives of piperazinyl-benzothiazinones as promising antimycobacterial agents. Archiv der pharmazie 2022, 355, 11, 2200168. https://doi.org/10.1002/ardp.202200168.
- Identification of nitrofuranylchalcone tethered benzoxazole-2-amines as potent inhibitors of drug resistant Mycobacterium tuberculosis demonstrating bactericidal efficacy. Bioorganic & Medicinal Chemistry 2022, 64, 116777. https://doi.org/10.1016/j.bmc.2022.116777.
- Synthesis of a new series of quinoline/pyridine indole-3-sulfonamide hybrids as selective carbonic anhydrase IX inhibitors. Bioorganic & Medicinal Chemistry Letters 2022, 70, 128809. https://doi.org/10.1016/j.bmcl.2022.128809.
- Biomimetic synthesis, characterization and mechanism of formation of stable silver nanoparticles using Averrhoa carambola L. leaf extract. Materials Letters 2015, 160, 566-571. https://doi.org/10.1016/j.matlet.2015.08.048.
Ongoing Research Projects
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Structure-based design and bio-evaluation of pyrazole/indole-based novel bacterial topoisomerase inhibitors as promising chemotypes to combat drug-resistant infection.
Expertise
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Structure-based Drug Design and Discovery
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Medicinal Chemistry and Chemical Biology
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Novel Antibacterial and Anticancer Chemotherapeutics Development
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Hit-to-Lead optimization for Biologically active compound
