rmahadev@gitam.edu
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Dr. Ravikiran Mahadevappa is a molecular biologist based in GITAM School of Sciences, Bengaluru, India. He holds an International PhD from Aarhus University, Denmark. His research is centered on cancer biology, genomics, and cancer immunology, with a strong focus on understanding the mechanisms behind tumor heterogeneity. He is also deeply interested in exploring tumor immune infiltration and genomic instability throughout cancer development.
Research Publications
- Saha S, Pradhan N, B N, Mahadevappa R, Minocha S, Kumar S. Cancer plasticity: Investigating the causes for this agility. Semin Cancer Biol. 2023 Jan;88:138-156. doi: 10.1016/j.semcancer.2022.12.005. Epub 2022 Dec 28. PMID: 36584960.
- Mughal MJ, Chan KI, Mahadevappa R, Wong SW, Wai KC, Kwok HF. Over-Activation of Minichromosome Maintenance Protein 10 Promotes Genomic Instability in Early Stages of Breast Cancer. Int J Biol Sci. 2022 May 29;18(9):3827-3844. doi: 10.7150/ijbs.69344. PMID: 35813483; PMCID: PMC9254470.
- Mughal MJ, Mahadevappa R, Kwok HF. DNA replication licensing proteins: Saints and sinners in cancer. Semin Cancer Biol. 2019 Oct;58:11-21. doi: 10.1016/j.semcancer.2018.11.009. Epub 2018 Nov 28. PMID: 30502375.
- Li B, Lyu P, Xi X, Ge L, Mahadevappa R, Shaw C, Kwok HF. Triggering of cancer cell cycle arrest by a novel scorpion venom-derived peptide-Gonearrestide. J Cell Mol Med. 2018 Sep;22(9):4460-4473. doi: 10.1111/jcmm.13745. Epub 2018 Jul 11. PMID: 29993185; PMCID: PMC6111814.
- Mahadevappa R, Neves H, Yuen SM, Jameel M, Bai Y, Yuen HF, Zhang SD, Zhu Y, Lin Y, Kwok HF. DNA Replication Licensing Protein MCM10 Promotes Tumor Progression and Is a Novel Prognostic Biomarker and Potential Therapeutic Target in Breast Cancer. Cancers (Basel). 2018 Aug 22;10(9):282. doi: 10.3390/cancers10090282. PMID: 30135378; PMCID: PMC6162382.
Ongoing Research Projects
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Understanding the tumor diversity of triple-negative breast cancer (TNBC) through MCM10 and its transcriptional gene signatures
Expertise
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Research Design and Development
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Curriculum Design
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Establishing lab infrastructure
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Developing academic and Industrial Collaborations
