rudupi@gitam.edu
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ORCiD
Dr. Ramagopal graduated in 2001 from the Department of Physics, IISc, Bangalore, and received “Kumari L. A. Meera” Best PhD thesis prize and Gold Medal. Dr. Ramagopal has contributed to the areas of de novo design of peptides and proteins, de novo structure determination of proteins and the structure ellucidation of several immune receptor:ligand complexes and uses these insights to develop soluble version of Fc-immune receptor conjugates with acceptable drug-like properties.
Research Publications
- Lankipalli S, , Mahadeva Swamy HS, Selvam D, Samanta D, Nair D, and and Ramagopal UA*. Cryptic association of B7-2 molecules and its implication for clustering. 2021, Protein Science,30(9),1958-1973,
- Kundapura S, Ramagopal UA*. The CC’ loop of IgV domains of the immune checkpoint receptors, plays a key role in receptor:ligand affinity modulation, 2019, Scientific Reports. Dec 16;9(1):19191. doi: 10.1038/s41598-019-54623-y
- Ramagopal UA, Liu W, Garrett S, Yan Q, Srinivasan M, Wong S, Bell A, Mankikar S, Vangipuram R, Deshpande S, Korman A, Almo, SC. Structural basis for cancer immunotherapy by the first-in-class checkpoint inhibitor Ipilimumab. 2017, Proc. Nat. Acad. Sci. (USA), 114(21), E4223-E4232.
- Pavithra GC, Ramagopal UA*. Crystal structures of APRT from Francisella tularensis: An N-HN hydrogen bond imparts adenine specificity in adenine phosporibosyltransferases. 2018, FEBS J, 285(12):2306-2318
- Bhowmick T,Ghosh S, Ramagopal UA, Dey D, Ramakumar S, Nagaraja S. Structure based inhibition provides an insight into the HU mediated regulation in Mycobacterium tuberculosis. 2014, Nature Communications, 5, 4124
Ongoing Research Projects
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(1) Rational design of immune receptors/ligands for use in checkpoint blockade immunotherapy (
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2) Structural analysis of enzymes and their complexes and discovery of natural products using structural biology approaches.
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(3) New model for cell signaling
Expertise
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Structural biology, biophysical techniques, molecular biology, rational design of therapeutic proteins
