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P Purushotham

Associate Professor

Education

Ph. D.

Post-doctoral Research Associate (2013-2018) in Prof. Jochen Zimmer’s lab. Title of the research “Structural and Functional Characterization of Plant Cellulose Synthase (CESA’s) complex”. Ph.D in Plant Sciences from University of Hyderabad, Hyderabad, India, 2008- 2012. Thesis title “Hydrolytic and transglycosylation activities of Serratia proteamaculans 568 on chitinous substrates”. Mentor: Prof. Appa Rao Podile. Master of Science (M.Sc) in Biotechnology from S.V. University, India

Research Publications

  • Purushotham P, Ho R, Yu L, Fincher GB, Bulone V, Zimmer J. Mechanism of mixed linkage glucan biosynthesis by barley Cellulose Synthase-like CslF6 (1,3;1,4)-β-glucan synthase. Sci Adv. 2022 Nov 11;8(45): eadd1596.
  • Purushotham P*, Ho R*, Zimmer J. Architecture of a catalytically active homotrimeric plant cellulose synthase complex. Science. 2020; 369(6507):1089-1094. *Equal contribution. Research article Recommended in Faculty Opinions.
  • Cho S.H., Purushotham P, Fang C, Maranas C, Díaz-Moreno S.M., Bulone V, Zimmer J, Kumar M, Nixon B.T. Synthesis and self-assembly of cellulose microfibrils from reconstituted cellulose synthase. Plant Physiol. 2017;175(1):146-156.
  • Purushotham P, Cho S. H., Díaz-Moreno S. M., Kumar M, Nixon B.T., Bulone V, Zimmer J. A single heterologously expressed plant cellulose synthase isoform is sufficient for cellulose microfibril formation in vitro. Proc Natl Acad Sci U S A. 2016;113(40):11360-11365. The F1000 Article.
  • Purushotham P, and Podile, A.R. Synthesis of long-chain chitooligosaccharides by a hyper transglycosylating processive endo-chitinase of Serratia proteamaculans 568. J Bacteriol. 2012;194: 4260- 4271.

Expertise

  • Check Icon Biochemistry, Biotechnology, Glycobiology

Authored Books

  • Check Icon Sarma, P.V.S.R.N., Prakash, J.M, Das, S.N., Kaur, M., Purushotham P, and Podile A.R. Microbial chiti
  • Check Icon Purushotham P, Das, S.N., Sarma, P.V.S.R.N., Prakash, J.M, and Podile A.R. Chitin, chitosan and chitooligosaccharides: a treasure in store. Microbial Diversity Exploration and Bioprospecting. Reddy, S. Ram; Singara Charya, M. A.; Girisham, S (Eds.), Scientific Publishers, 2012. pp. 309-324.
  • Check Icon Das, S.N., Neeraja, Ch., Sarma, P.V.S.R.N., Prakash, J.M., Purushotham P, Kaur, M., Dutta, S., and Podile A.R., Microbial Chitinases for Chitin Waste Management. In: Satyanarayana, T., Johri, B.N., Prakash, A, (Eds.), Microorganisms in Environmental Management. Springer Inc., Netherlands;2012. pp.135-150.
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