sharihar@gitam.edu
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Sitaram Harihar received his Ph.D. in Biology from Utah State University, USA. He worked as a post-doctoral fellow at The University of Kansas Medical Center, USA and as a research fellow at the Institute of Molecular and Cell Biology (IMCB), Singapore. His research focusses on understanding the biology of cancer metastasis with a goal to develop more realistic and less aggressive approaches to control metastases.
Research Publications
- Vaidya KS, Harihar S, Phadke PA, Stafford LJ, Hurst DR, Hicks DG, Casey G, DeWald DB, Welch DR. Breast cancer metastasis suppressor-1 differentially modulates growth factor signaling. J Biol Chem (2008) Oct 17; 283(42):28354-60 https://doi.org/10.1074/jbc.M710068200
- Wu Y, McEwen GD, Harihar S, Baker SM, DeWald DB, Zhou A. BRMS1 expression alters the ultrastructural, biomechanical and biochemical properties of MDA-MB-435 human breast carcinoma cells: an AFM and Raman Microspectroscopy Study. Cancer letters (2010) Jul 1;293(1):82-91 https://doi.org/10.1016/j.canlet.2009.12.016
- Harihar S, Pounds KM, Iwakuma T, Seidah NG and Welch DR. Furin is the major proprotein convertase required for KISS1-to-kisspeptin processing PLoS One. (2014) Jan 13;9(1) https://doi.org/10.1371/journal.pone.0084958
- Harihar S, Ray S, Narayanan S, Santhoshkumar A, Ly T and Welch DR. Role of the tumor micro-environment in regulating the anti-metastatic effect of KISS1. Clin Exp Metastasis (2020) Apr;37(2):209-223. https://doi.org/10.1007/s10585-020-10030-6
- Harihar S and Welch DR. KISS1 metastasis suppressor in tumor dormancy: a potential therapeutic target for metastatic cancers? Cancer Metastasis Rev (2023) Jan, 42, 183-196 https://doi.org/10.1007/s10555-023-10090-6
Ongoing Research Projects
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DST-SERB Core Research Grant: Impact of post-translational modifications on the anti-metastatic activity of kisspeptins. Role: PI; Rs. 54,53,434; 1/2024 - 2027
Expertise
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Molecular and Cellular Mechanisms of Cancer Metastasis
