Harihar Sitaram

Associate Professor

Department of Life Sciences

GITAM School of Science

Visakhapatnam

Education

Ph. D.

sharihar@gitam.edu

Social Media

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ORCiD

Sitaram Harihar received his Ph.D. in Biology from Utah State University, USA. He worked as a post-doctoral fellow at The University of Kansas Medical Center, USA and as a research fellow at the Institute of Molecular and Cell Biology (IMCB), Singapore. His research focusses on understanding the biology of cancer metastasis with a goal to develop more realistic and less aggressive approaches to control metastases.

Research Publications

Vaidya KS, Harihar S, Phadke PA, Stafford LJ, Hurst DR, Hicks DG, Casey G, DeWald DB, Welch DR. Breast cancer metastasis suppressor-1 differentially modulates growth factor signaling. J Biol Chem (2008) Oct 17; 283(42):28354-60 https://doi.org/10.1074/jbc.M710068200
Wu Y, McEwen GD, Harihar S, Baker SM, DeWald DB, Zhou A. BRMS1 expression alters the ultrastructural, biomechanical and biochemical properties of MDA-MB-435 human breast carcinoma cells: an AFM and Raman Microspectroscopy Study. Cancer letters (2010) Jul 1;293(1):82-91 https://doi.org/10.1016/j.canlet.2009.12.016
Harihar S, Pounds KM, Iwakuma T, Seidah NG and Welch DR. Furin is the major proprotein convertase required for KISS1-to-kisspeptin processing PLoS One. (2014) Jan 13;9(1) https://doi.org/10.1371/journal.pone.0084958
Harihar S, Ray S, Narayanan S, Santhoshkumar A, Ly T and Welch DR. Role of the tumor micro-environment in regulating the anti-metastatic effect of KISS1. Clin Exp Metastasis (2020) Apr;37(2):209-223. https://doi.org/10.1007/s10585-020-10030-6
Harihar S and Welch DR. KISS1 metastasis suppressor in tumor dormancy: a potential therapeutic target for metastatic cancers? Cancer Metastasis Rev (2023) Jan, 42, 183-196 https://doi.org/10.1007/s10555-023-10090-6

Ongoing Research Projects

DST-SERB Core Research Grant: Impact of post-translational modifications on the anti-metastatic activity of kisspeptins. Role: PI; Rs. 54,53,434; 1/2024 - 2027

Expertise

Molecular and Cellular Mechanisms of Cancer Metastasis