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Debjit Khan

Debjit Khan

Associate Professor

Education

Ph. D.

Dr. Debjit Khan earned his MSc in Biophysics and Molecular Biology from the University of Calcutta, followed by a PhD in Indian Institute of Science, Bangalore. He did a stint as a postdoctoral fellow in the University of British Columbia/BC Cancer Agency in Canada and then spent substantial time as a researcher in the Cleveland Clinic, Ohio, USA where he was a Project Staff before joining Life Sciences, GITAM-BLR. He received INSA Young Scientist Medal in 2020 for his PhD work done in India.

Research Publications

  • 1. Khan D, Ramachandiran I, Vasu K, China A, Khan K, Cumbo F, Halawani D, Terenzi F, Zin I, Long B, Costain G, Blaser S, Carnevale A, Gogonea V, Dutta R, Blankenberg D, Yoon G, Fox PL. Homozygous EPRS1 missense variant causing hypomyelinating leukodystrophy-15 alters variant-distal mRNA m6A site accessibility. Nature Communications (2024). DOI: 10.1038/s41467-024-48549-x
  • 2. Khan D, Terenzi F, Liu G, Ghosh PK, Ye F, Nguyen K, China A, Ramachandiran I, Chakraborty S, Stefan J, Khan K, Vasu K, Dong F, Willard B, Karn J, Gack MU, Fox PL. A viral pan-end RNA element and host complex define a SARS-CoV-2 regulon. Nature Communications (2023). DOI: 10.1038/s41467-023-39091-3
  • 3. Vasu K, Khan D, Ramachandiran I, Blankenberg D, Fox PL. Analysis of nested alternate open reading frames and their encoded proteins. Nucleic Acids Research-Genomics and Bioinformatics (2022). DOI: 10.1093/nargab/lqac076
  • 4. Khan D+, Katoch A+, Das A, Sharathchandra A, Lal R, Roy P, Das S, Chattopadhyay S, Das S. Reversible induction of translational isoforms of p53 in glucose deprivation. [+Equal contribution] Cell Death and Differentiation (2015). DOI: 10.1038/cdd.2014.220
  • 5. Khan D, Sharathchandra A, Ponnuswamy A, Grover R, Das S. Effect of a natural mutation in the 5′ untranslated region on the translational control of p53 mRNA. Oncogene (2013). DOI: 10.1038/onc.2012.422

Ongoing Research Projects

  • Check Icon 1. Translational control through viral SPEAR system and cellular SPEAR-analogous systems
  • Check Icon 2. Regulation of gene expression by mRNA modifications

Expertise

  • Check Icon Translational control of gene expression in cellular stress and physiology
  • Check Icon Translational control of gene expression in RNA viruses
  • Check Icon mRNA modifications (epitranscriptomics) in health and disease
  • Check Icon RNA-based therapeutics
  • Check Icon RNA-protein interactions
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